MyBioSource.com's Anti-N-Cadherin antibody (monoclonal) is a Mouse monoclonal antibody. The Anti-N-Cadherin antibody (monoclonal) was generated using Cadherin 2, CD325, Cdh2, glo, N Cadherin, NCAD, and pac as the antigen. It reacts with Human, Mouse, Rat, Chicken/Bird, and Rabbit. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Description: Mouse IgG monoclonal antibody for N-Cadherin, cadherin 2, type 1, N-cadherin (neuronal) (CDH2) detection. Tested with WB, IHC-F in Human, mouse, rat, rabbit, chicken. No cross reactivity with other proteins. Uniprot ID: P19022
Background: N-cadherin(NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver cell adhesion molecule(L-CAM). N-Cadherin, also known as Cadherin-2, encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene(including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis